Frontiers Journal of Pediatrics and Neonatology (FJPN)

Probiotics Use In A Neonatal Unit In Port Sudan / Sudan: This Combination Is Effective And Should Be Part Of The Routine Care.

Keywords : Combined Probiotics, Preterm Infants, Mortality, NEC, Sepsis, Feeding Intolerance, Nosocomial Infections.


Background: Survival of preterm neonates resulted in a multitude of morbidities. One of the efforts to decrease this is the use of probiotics. Worldwide many investigators tested a probiotic or another. In the effort to reduce neonatal mortality in Sudan, the author tried three combined probiotics. To my knowledge, worldwide nobody had tested such a combination, no such research in Sudan or in the Arab World at the moment.

Objectives: The primary objective is to test the effect on incidence of feeding intolerance, NEC, sepsis, and death in the study group, compared to the historical cohort of infants of same gestational age group, not given probiotics. The secondary objective is to test drug tolerability, side effect, prevention of nosocomial infection, and length of hospitalization in the study group.

Method: This is a pilot unicentral, longitudinal prospective, hospital-based study, included preterm infants 26 to 37 wks of gestation. Exclusion criteria: severe congenital malformations, GIT defects, refusal of one/both parents. 250,000,000 mixed bacterial units are given orally, OD. Duration of treatment per infant was till maturity. Data analyzed by SSPS 20 and manually.

Results and Conclusion: The intervention effectively decreased the mortality (p < 0.03) and morbidity (p < 0.02) and abolished feeding intolerance, is well tolerated, has no adverse effect, and significantly shortened the hospitalization period (p< 0.05).