Frontiers Journal of Pediatrics and Neonatology (FJPN)

Subacute Sclerosing Panencephalitis: Will This Monster Disease Raise From The Death

Abstract

Background: Subacute Sclerosing PanEncephalitis (SSPE) is a devastating disease of the brain which was considered as vanishing disease due to world-wide and successful measles immunization program. The recent pan- endemic of measles affecting many infants and young children may cause the unfortunate reappearance of SSPE

Objective: To describe the etiology, complex clinical features, diagnostic tools and the pathophysiology of the disease as a reminder for those physicians who grew-up in the ere without SSPE

Results: The recent epidemic of measles, the clinical course and preventive measures will be reviewed in brief. In addition, personal experience in diagnosis and treatment of a large group pf patients with SSPE, and some thoughts about possible mechanism will be discussed in some length

Reference:

Ø  WHO report:  Measles in Europe: Copenhagen, 7 February 2019?

Ø  Mekki M, Eley B, Hardie D, Wilmshurst JM. Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions Dev Med Child Neurol. 2019 Jan 25

Ø  Gadoth N. Subacute sclerosing panencephalitis (SSPE) the story of a vanishing disease. Brain Dev. 2012 Oct;34(9):705-11.

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