Background: Subacute Sclerosing PanEncephalitis (SSPE) is a devastating disease of the brain which was considered as vanishing disease due to world-wide and successful measles immunization program. The recent pan- endemic of measles affecting many infants and young children may cause the unfortunate reappearance of SSPE
Objective: To describe the etiology, complex clinical features, diagnostic tools and the pathophysiology of the disease as a reminder for those physicians who grew-up in the ere without SSPE
Results: The recent epidemic of measles, the clinical course and preventive measures will be reviewed in brief. In addition, personal experience in diagnosis and treatment of a large group pf patients with SSPE, and some thoughts about possible mechanism will be discussed in some length
Ø WHO report: Measles in Europe: Copenhagen, 7 February 2019?
Ø Mekki M, Eley B, Hardie D, Wilmshurst JM. Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions Dev Med Child Neurol. 2019 Jan 25
Ø Gadoth N. Subacute sclerosing panencephalitis (SSPE) the story of a vanishing disease. Brain Dev. 2012 Oct;34(9):705-11.